Updated: Oct 16
Clinical Research Division Biologic Nutrigenomic Health Research Corp.
688-2397 King George Hwy, BC V4A 7E9 www.biologicpharmamedical.com
Research/Trial Director: Prof Franco Cavaleri BSc NB
Original post: December 31, 2010
Investigative report by Research Director Franco Cavaleri BSc NB
Glucosamine has become so widely used to prevent joint disease that annual sales of the supplement have reached close to a billion dollars as per reports in 2009. For some time though, controversial evidence has indicated that this supplement might be an aggravator of the diabetic condition. Recent studies are bringing more light on the possibility.
Investigative trials at Biologic Health Research Corp have isolated the pathway that glucosamine, does in fact, influence to impose its adverse action on insulin. This better understanding of how glucosamine may interact shows that the vulnerability may only be in those who have already developed mild to advanced insulin resistance or have been diagnosed with diabetes.
What is insulin resistance?
Insulin resistance is a pre-diabetic state. Diabetes is an advanced state of insulin resistance. When we eat a meal, our pancreas manufactures and secretes insulin. Insulin triggers receptors on the insulin responsive cells causing them to open the cell surface gateways to allow blood sugar and other nutrients in for energy production and tissue and biochemical construction. When these receptors lose sensitivity to insulin and cannot respond to the hormone’s signal, a degree of insulin resistance has developed.
The type II diabetic state is characterized by a loss of as much as 65% of this insulin sensitivity. Prediabetic states, however, still present a health challenge that is rarely recognized but experienced as a nonspecific sluggish metabolism, poor energy, memory insufficiency, blood sugar mismanagement, poor body fat control, loss of lean muscle and even lower mental and physical performance potential.
As we age, insulin resistance tends to advance. The development of this metabolic sluggishness is also compounded by lifestyle choices such as a processed and refined high glycemic index diet, sedentary lifestyle. Common environmental toxins like pesticides that might be concentrated in food can also contribute to insulin impediment.
Why the conflicting opinions on glucosamine’s influence?
In individuals where lifestyle, genetic predisposition and age are all contributing to insulin desensitization and diabetes, the addition of high glucosamine levels to the diet to treat osteoarthritis may be too much for a system trying to cope. Healthier insulin activity in the younger individual with a healthier lifestyle might not be negatively affected by the added glucosamine strain. These variances amongst us all contribute to the conflicting results reported by researchers.
However, one thing remains constant. Individuals who require glucosamine supplementation to treat osteoarthritis are usually well into adulthood and close to or well into senior years. As a result insulin resistance is likely in an advanced state especially if lifestyle factors (less than healthy) have compounded the natural age-related decline. In these individuals, ongoing high doses of glucosamine supplementation could very well be an aggravator to an already strained situation.
What’s the solution?
Glucosamine supplements present formidable health benefits to those who need them as a reactive treatment for advanced arthritic conditions. They’re also fantastic preventive supplements that can be used daily to prevent the onset of premature joint disease for those of us who are physically active or are vulnerable to joint illness due to genetic or other predispositions. The solution is in using a properly formulated glucosamine supplement that provides powerful synergy built into the formula so that smaller amounts of glucosamine can deliver the result.
The latest joint health technology to hit the billion dollar category is a natural eggshell membrane glucosamine that is showing in the laboratory and in real life to provide incredible results with standard setting small doses. The potency is ultimately based on the remarkable synergy of the natural compounds found in the silky, rubbery membrane that lines the inner face of the eggshell.
The glucosamine from whole eggshell membrane is not isolated or reacted but rather allowed to exist in its natural matrix containing NAG, glucosamine, hyaluronic acid, sulfur, chondroitin as well as collagen and other proteins essential for healthy connective tissue. Research indicates that these the eggshell membrane connective tissue building blocks might be more efficiently absorbed.
Clinical research using doses of one 500 mg pill per day of this very eggshell membrane powder demonstrates therapeutic results in just 10 days for most in the test group and as long as 30 days for more difficult cases. Eggshell membrane supplies a matrix of important connective tissue building blocks
Eggshell membrane supplies a matrix of important connective tissue building blocks that supports skin, bone, tendons, ligaments, cartilage and more. In addition, eggshell membrane delivers potent therapeutic anti-inflammatory activity. And it does so without the same risks associated with long term high doses of typical purified and reacted glucosamine sources. Eggshell membrane seems to be the better preventive choice for active individuals and definitely the safest therapeutic choice for ailing arthritics.
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