Peripheral neuropathy can be a nagging painful experience the cause of which can be more than just diabetes. It can be caused by cancer, side-effects of medications, chemical toxins, heavy metals, alcoholism and even nutritional deficiencies. Neuropathy refers specifically to the damage caused to the nerves which results in tingling and burning sensations and can lead to unbearable pain in advanced stages.
Medications are available to treat the pain and discomfort, however, the most effective approach is prevention and prophylactic treatments that can slow and even stop the progress of the disease. Research on dietary changes, Curcumin and exogenous ketone supplementation to facilitate dietary carbohydrate restriction is showing promising results. At a cellular level the changes that the right Curcuminoid preparation can induce is clear evidence of the mechanism by which Curcumin BioBDMC can be a great fit in the treatment protocol for neuropathies.
Research has shown that MAP kinase inhibitors can play a central role in therapy of neural diseases [9]. Downregulation of MAPK/MSK1 pathway suppresses neurodegeneration [10, 11] as these kinases play a central role in the transcription regulation of inflammatory cytokines in peripheral tissues and the central nervous system [12, 13]. Bisdemethoxycurcumin the principle bioactive fraction in Curcumin BioBDMC™ has been shown to exhibit profound inhibition of MSK1 activity by way of nuclear and cytosolic MSK1 status downregulation whereby regular curcumin extracts had no significant effect [5]. The combined down-modulation of MSK1 and NF-kB plays a key role in cytokine modulation involved in this inflammatory activity; an influence effectively delivered by Curcumin BioBDMC™. Clinical trials using Curcumin BioBDMC™ drug variations will be crafted to further investigate this widely needed treatment for so many in need.
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