Updated: Jun 5, 2021
by Franco Cavaleri BSc PhDc
Original post: August 11, 2017
(Picture> Franco Cavaleri 1992 Mr IFBB North America) Imagine being able to get into the gym to train a body part more frequently than your competition can. What does that mean to you in six months of steady training? Imagine recovering faster from a stage-to-stage or day-to-day workload in your competitive sport such as a cycling tour; a triathlon competition; or an all weekend cross-fit event. The advantage is possible with Curcumin BDM30™.
Research demonstrates that myogenic potential and anabolic drive can be limited by mismanaged NF-kB. NF-kB is a transcription factor responsible for regulating as many as 150 genes that manage and beckon the immune system and inflammatory response. Anabolic drive and recovery of lean muscle is meticulously orchestrated by the cytokines that NF-kB manages, including TNFα. TNFα partakes in and advances inflammation that is necessary but can also be a limiting factor in your pursuit to maximum form.
(Picture> Franco Cavaleri 1992 Mr IFBB North America) The inflammatory process plays an important role in recovery and regeneration of tissue, including myogenesis (muscle generation). Skeletal muscle cells are said to be one of the most adaptable cells/tissue of the body. The underlying objective with resistance training, for example, is to evoke microtrauma of the working skeletal muscle cells resulting in cell signalling that activates satellite cells in the vicinity of the strained fiber. This activation prompts aggregation and fusing of these cells with mature muscle fibers. This is ultimately the compensatory hypertrophy we expect to occur as an adaptation feature to the extra-ordinary workload, adding muscle mass and strength over time.
That prolonged soreness that often persists to the next training day, however, is a problem. Prolonged survival of that post-workout soreness is indicative of longstanding TNFα and inflammation; and interference with maximum recovery potential. That means interference with your own human potential.
(Picture> Franco Cavaleri 1992 Mr IFBB North America) Research shows TNFα also inhibits myogenesis the mechanism of which is repression of MyoD protein. MyoD expression is central to cell restoration and differentiation – it’s essential to the generation of muscle tissue. Prolonged survival of the inflammatory process to inhibit MyoD protein interferes with recovery, immunity and myogenic (muscle building) potential. Downregulation of training-related and age-related inflammatory activity has both an anticatabolic influence and promotes anabolic drive to restore maximum muscle protein anabolism.
This recovery enhancement from intense training was, in fact, the reason for my obsessive use of curcumin as a recovery agent in the early 1990’s before I turned to therapy for inflammatory disease as the focus of my curcumin work. Whether this strategy contributed to my success to the first place podium almost every time I competed and how much it contributed are yet to be completely demonstrated. Nevertheless, today we are uncovering scientific pathways that demonstrate how and how likely it was to have contributed. Knowing what I experienced and knowing what I know scientifically today, I use it daily. … and if I were competing it would certainly be a central component of my performance program.
Although curcumin can deliver an inhibitory effect on NF-kB transactivation and transcription of inflammatory cytokines, including TNFα, the new discoveries showing MSK1 inhibition by BDMC (Curcumin III) changes the game. Curcumin BDM30™ is a result of these discoveries and it stops inflammation at a subcellular level where inflammatory proteins are generated.
Investing the time and effort into training to improve health and advance performance requires the best return possible. Imagine again being able to get into the gym to train a body part or work a training cycle more frequently than your competition can. Imagine again, maximising MyoD expression and anabolic drive. This time get with the program to make it happen with Curcumin BDM30™ taken daily just before or after the workout. If you don’t, someone you know will likely beat you to it and may even do so to the first place podium.
Franco Cavaleri, BSc, PhDc, is The Rhema Group’s Chief Science Officer. He is the principal research scientist at Biologic Pharmamedical. Franco Cavaleri is also a former IFBB Mr. North America having practiced the science.
Conflict of Interest Statement. The author/researcher is the owner of a biomedical research group – Biologic Nutrigenomics Health Research Corp and Biologic Pharmamedical Research, that funds and executes research on the pharmacology of nutritional and nutraceutical agents that are studied in the context of disease pathology including characteristics that have been associated with inflammation and dementias.
The research on these findings continues at clinical levels to further investigate the full indication-specific potential of this discovery. The author/researcher is also the owner of related Intellectual Properties. author copyright Franco Cavaleri PhDc