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Mastering Insulin: A Deep Dive into Genetic Influences on Metabolism

Mastering Insulin: A Deep Dive into Genetic Influences on Metabolism

Franco Cavaleri sheds light on the often misunderstood dynamics of insulin resistance and its connection to type 2 diabetes.

Understanding Insulin Resistance

As we age, insulin resistance becomes a common occurrence, a desensitization to insulin's signal. When insulin is released to regulate blood sugar levels, it triggers receptors in peripheral tissues, acting like a key in a lock mechanism.

Insulin Structure Matters

Insulin's structure, a complex three-dimensional arrangement of amino acids, is crucial. Cavaleri explains how mutations in the insulin gene, passed through generations, can cause structural deviations, affecting the signaling process. This leads to varying degrees of insulin resistance.

Impact on Metabolism

Insulin mutations influence metabolism. While some may struggle unknowingly due to mild mutations, others may face early diagnosis. Severity varies, affecting the body's ability to burn, store fat, and metabolize energy. It's a nuanced interplay between genetics and metabolic efficiency.

Receptor Site Mutations

Not all insulin resistance is gene-related. Cavaleri introduces mutations affecting receptor sites, separate from insulin genes. These mutations, especially in the A and B units of the receptor, cause desensitization and respond well to intermittent fasting.

Insulin Resistance and Intermittent Fasting

Cavaleri hints at the effectiveness of intermittent fasting for those with receptor site mutations. In part 2, he delves deeper into how intermittent fasting relates to combating insulin resistance

"If you have an insulin gene mutation, your insulin is not signaling as well as someone else's insulin who doesn't have the mutation."

Insulin resistance is a multifaceted issue, influenced by genetics and lifestyle. Franco Cavaleri's insights provide a clearer picture of the intricate relationship between insulin, mutations, and type 2 diabetes.

To delve deeper into this topic, watch the full video on YouTube and visit

Learn more about managing insulin resistance and explore Franco Cavaleri's books at

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